A nutrigenetic approach to examine the relationship between vitamin B12 status and cardio?metabolic traits in multiple ethnic groups – findings from the GeNuIne Collaboration

Low vitamin B12 concentration has been shown to be a risk factor for cardio-metabolic traits in numerous observational studies; however, the relationship remained inconsistent. It is possible that certain genotypes jointly contribute diseases and deficiency, these may modulated by dietary factors. The main objective of this article summarise findings from GeNuIne (Gene-Nutrient Interactions) Collaboration on effect gene–nutrient interactions concentrations disease factors population-based studies different ethnic groups. Interactions between B12-related single-nucleotide polymorphisms (SNPs) protein energy intake (%) waist circumference (Pinteration =0.002) body fat percentage (Pinteraction =0.034) were observed Sri Lankan Indonesian populations, respectively. In study Brazilian adolescents, metabolic SNPs showed significant interaction with carbohydrate intakes oxidised low-density lipoprotein cholesterol homocysteine concentrations, Asian Indian population, an association obesity-related (p = 0.018) was observed. summary, multiple groups show genetically low modified intake. Further utilising larger sample sizes are needed confirm or refute our findings.